excitatory amino acid การใช้

• Examples include excitatory amino acid receptor antagonists, and excitatory amino acid reuptake inhibitors.
• Examples include excitatory amino acid receptor antagonists, and excitatory amino acid reuptake inhibitors.
• They induced shedding in Xenopus laevis by adding the excitatory amino acid L-aspartate.
• This compound is also routinely used to isolate glutamatergic ( excitatory amino acid ) receptor function.
• As NMDA receptor antagonists, dextrorphan and dextromethorphan inhibit the excitatory amino acid and neurotransmitter glutamate in the brain.
• EAAT5 is expressed predominantly in the retina, has high affinity for the excitatory amino acid L-glutamate.
• EAAT4 is expressed predominantly in the cerebellum, has high affinity for the excitatory amino acids L-glutamate.
• Members of the family include : several mammalian excitatory amino acid transporters, and a number of bacterial transporters.
• It acts as an antiexcitotoxic and anticonvulsant, most likely through acting as an antagonist at excitatory amino acid receptors.
• Ceftriaxone seems to increase excitatory amino acid transporter-2 pump expression and activity in the central nervous system, so has a potential to reduce glutamatergic toxicity.
• In the brain, excitatory amino acid transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels.
• A small number of genes which were suspected to carry a mutation for AHC have been screened for sodium channel protein mutations, ATP pump mutations, and excitatory amino acid transmitter mutations.
• NSS carriers are structurally distinct from the second more-restricted family of plasma membrane transporters, which are responsible for excitatory amino acid transport ( see TC # 2 . A . 23 ).
• For its part, OPI also extracted a rare excitatory amino acid ( kainic acid ) and marketed it to some 300 neurological labs, universities and pharmaceutical companies in over 40 countries over the next decade.
• This may be achieved by regulating the excitatory amino acid systems that are responsible for changes in the strength of synaptic connections as well as enhancing BDNF expression, although these findings are based largely on preclinical studies.
• Research conducted by Dr . Christopher Ranger with the USDA Agricultural Research Service and other collaborating scientists have demonstrated the excitatory amino acid called quisqualic acid present within the flower petals is responsible for causing paralysis of the Japanese beetle.
• Amara's laboratory examined the impact of psychostimulant and antidepressant drugs on the signaling properties, physiology and regulation of two families of sodium-dependent neurotransmitter transporters, which are the biogenic amine and the excitatory amino acid carriers.
• SB-271046 was found to increase levels of the excitatory amino acid neurotransmitters glutamate and aspartate, as well as dopamine and noradrenaline in the frontal cortex and hippocampus of rats, and 5-HT 6 antagonists have been shown to produce nootropic effects in a variety of animal studies.
• Binge drinking regimes are associated with causing an imbalance between inhibitory and excitatory amino acids and changes in monoamines release in the central nervous system, which increases neurotoxicity and may result in cognitive impairments, psychological problems and in long-term heavy binge drinkers may cause irreversible brain damage in both adolescents and adults.
• He was research scientist at the University of Bristol from 1983 to 1994, and received a PhD at the same university in 1988 for his research on ligand binding and electrophysiological studies of excitatory amino acid receptors in the rat central nervous system, under the guidance of the organic chemist Jeffrey C . Watkins.